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Right prefrontal slow repetitive transcranial magnetic stimulation in schizophrenia: a double-blind sham-controlled
E Klein1, Y Kolsky, M Puyerovsky
1Department of Psychiatry, Rambam Medical Center, Haifa, Israel.
Background:
The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia.
Methods:
Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatment and were rated before and after treatment for positive, negative, and depressive symptoms.
Results:
Thirty-one subjects (rTMS = 16, sham = 15) completed a 2-week treatment protocol. No serious adverse effects were reported; however, rTMS was not superior to sham treatment on any of the clinical ratings.
Conclusions:
In contrast to our previous positive findings in major depression, right prefrontal slow rTMS does not appear to have a beneficial effect for actively psychotic patients with schizophrenia.