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Related Experiment Videos

Mixed polymer coating for modified release from coated spheroids.

Y T Tan1, P W Heng, L S Wan

  • 1School of Pharmaceutical Sciences, University of Science Malaysia, Minden, Penang, Malaysia. yvonne@usm.my

Pharmaceutical Development and Technology
|December 1, 1999
PubMed
Summary

Formulating modified-release drug spheroids with a specific hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) ratio of 3:1 optimizes prolonged drug release. Additives like PVP and PEG enhance coating integrity for controlled drug delivery.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Modified-release drug formulations are crucial for optimizing therapeutic efficacy and patient compliance.
  • Controlling drug release rates requires precise formulation of coating materials.

Purpose of the Study:

  • To develop modified-release drug spheroids using a mixed polymer coating system.
  • To investigate the impact of hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) ratios on drug release kinetics.
  • To evaluate the role of additives in enhancing coating properties.

Main Methods:

  • Formulation of drug spheroids using a rotary processor.
  • Coating of spheroids with an aqueous HPMC/NaCMC mixture in a bottom-spray fluidized bed.
  • Dissolution studies to assess drug release profiles.

Related Experiment Videos

  • Scanning electron microscopy (SEM) for coating integrity analysis.

    • Main Results:

    • Additives (PVP, PEG) improved coat flexibility and integrity, retarding drug release.
    • Increased coating levels generally decreased drug release rate.
    • An optimal HPMC to NaCMC ratio of 3:1 was identified for prolonged drug release.
    • Drug release kinetics followed a biexponential first-order model.

    Conclusions:

    • The ratio of HPMC to NaCMC is a critical factor in controlling dissolution T50% for modified-release spheroids.
    • A 3:1 HPMC:NaCMC ratio effectively prolongs drug release.
    • The synergistic viscosity of HPMC and NaCMC plays a significant role in retarding drug release.