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Related Experiment Videos

Hypotestosteronemia in chronically critically ill men.

D M Nierman1, J I Mechanick

  • 1Department of Medicine, Mount Sinai Medical Center, New York, NY 10029-6574, USA. dnierma@smtplink.mssm.edu

Critical Care Medicine
|December 1, 1999
PubMed
Summary
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Chronically critically ill men exhibit a high prevalence of low testosterone (hypotestosteronemia), potentially hindering recovery. Further research is needed to explore testosterone therapy

Area of Science:

  • Endocrinology
  • Critical Care Medicine

Background:

  • Critically ill patients often experience hormonal imbalances.
  • Hypotestosteronemia is common in critically ill men, but its prevalence in chronically critically ill (CCI) populations is not well-defined.

Purpose of the Study:

  • To determine the prevalence of hypotestosteronemia in chronically critically ill (CCI) men.

Main Methods:

  • A prevalence survey was conducted in a step-down respiratory care unit (RCU).
  • Thirty ventilator-dependent CCI men transferred from intensive care units (ICUs) were assessed.
  • Total and bioavailable testosterone (bioT) levels were measured within 48 hours of RCU admission.

Main Results:

  • 96% of patients (29 out of 30) had bioavailable testosterone (bioT) levels below the normal range for their age.

Related Experiment Videos

  • Average bioT concentration was 19+/-20 ng/dL, representing 16% of total testosterone.
  • A weak positive correlation was observed between bioT levels and the duration of ICU stay prior to RCU transfer, though this was not statistically significant when one outlier was removed.

    • Conclusions:

    • Chronically critically ill men demonstrate a very high prevalence of hypotestosteronemia.
    • This hormonal deficiency may impede patient recuperation and rehabilitation.
    • Further studies are warranted to investigate the potential benefits of testosterone supplementation for improving recovery in these patients.