Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myopathy in critically ill patients.

E Hund1

  • 1Department of Neurology, Ruprecht-Karls University, Heidelberg, Germany.

Critical Care Medicine
|December 1, 1999
PubMed
Summary

Critically ill patients frequently develop myopathy, a muscle disorder that can prolong intensive care unit stays. Avoiding corticosteroids and muscle relaxants may help prevent this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Hereditary transthyretin amyloidosis].

Der Nervenarzt·2014
Same author

[Septic encephalopathy].

Deutsche medizinische Wochenschrift (1946)·2007
Same author

[Critical illness myopathy in intensive care patients. Pathogenetic concepts and clinical management].

Der Anaesthesist·2006
Same author

[Neuromuscular complications of sepsis: "Critical illness" polyneuropathy and myopathy].

Deutsche medizinische Wochenschrift (1946)·2006
Same author

[Interdisciplinary guidelines on diagnosis and treatment for extracerebral amyloidoses--published by the German Society of Amyloid Diseases (www.amyloid.de)].

Deutsche medizinische Wochenschrift (1946)·2006
Same author

[Niemann-Pick disease type C--a neurometabolic disease through disturbed intracellular lipid transport].

Der Nervenarzt·2003

Area of Science:

  • Critical care medicine
  • Neurology
  • Pathology

Background:

  • Myopathic changes are common in intensive care unit (ICU) patients.
  • Understanding these changes is crucial for improving patient outcomes.

Purpose of the Study:

  • To review the latest information on the manifestation, clinical settings, pathophysiology, and histomorphologic changes of myopathy in critically ill patients.
  • To synthesize current knowledge on ICU-acquired myopathies.

Main Methods:

  • Comprehensive literature search of the MEDLINE database and other relevant sources.
  • Selection of studies focusing on myopathic complications in critically ill patients.
  • Extraction and synthesis of applicable data from selected studies.

Main Results:

  • Three main types of ICU myopathy identified: critical illness myopathy, myosin filament loss, and acute necrotizing myopathy.
  • Potential causes include sepsis mediators, high-dose corticosteroids, muscle relaxants, and critical illness neuropathy.
  • Muscle membrane inexcitability is another identified mechanism for severe weakness in ICU patients.

Conclusions:

  • Myopathy is frequent in critically ill patients, potentially prolonging ICU stay and rehabilitation.
  • Corticosteroids and muscle relaxants may trigger ICU myopathy and should be used cautiously.
  • Further research into the pathophysiology of ICU myopathy is urgently needed.

Related Experiment Videos