Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type I interferons and the Th1/Th2 paradigm.

F Sinigaglia1, D D'Ambrosio, L Rogge

  • 1Roche Milano Ricerche, Italy. francesco.sinigaglia@roche.com

Developmental and Comparative Immunology
|December 1, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase-locked dual-loop optical fiber gyroscope.

Optics letters·2025
Same author

Ultra-broadband high-resolution microdroplet spectrometers for the near infrared.

Optics letters·2021
Same author

Light pressure in droplet micro-resonators excited by free-space scattering.

Optics letters·2021
Same author

A kinetics-based approach to amyloid PET semi-quantification.

European journal of nuclear medicine and molecular imaging·2020
Same author

Approaching the transit time limit for high-precision spectroscopy on metastable CO around 6 μm.

Physical chemistry chemical physics : PCCP·2019
Same author

Prognostic Value of <sup>18</sup>F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel.

Contrast media & molecular imaging·2019
Same journal

Characterization of interleukin-20 from black carp and its role in the antiviral innate immunity.

Developmental and comparative immunology·2026
Same journal

The spatiotemporal immune response patterns of Gryllus bimaculatus to infection by the bioinsecticide Metarhizium anisopliae.

Developmental and comparative immunology·2026
Same journal

Characterization and determination of the immunomodulatory activity of intestinal microbiota microorganisms isolated from free-range Cornu aspersum snails in olive groves before and after aestivation.

Developmental and comparative immunology·2026
Same journal

Comprehensive analysis of pathogenic mechanisms of Enterobacter cancerogenus ECL9 in silkworms.

Developmental and comparative immunology·2026
Same journal

Isolate-Dependent Pathogenicity and Host-Pathogen Interactions of Toxigenic Penicillium roqueforti in the Galleria mellonella Model.

Developmental and comparative immunology·2026
Same journal

PPARγ mediates selenomethionine-induced suppression of NF-κB signaling in bovine endometrial epithelial cells.

Developmental and comparative immunology·2026
See all related articles

Interferons (IFNs) critically influence T helper cell differentiation, with type I IFNs showing species-specific effects on Th1 responses. This impacts understanding of conditions like multiple sclerosis (MS).

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • Recent advances highlight cytokines from innate immunity, like interleukin-12 (IL-12) and interferons (IFNs), as key drivers of CD4+ T helper cell subset differentiation.
  • Understanding these differentiation pathways is crucial for immunology and disease research.

Purpose of the Study:

  • To review recent data on the divergent roles of IFNs in human versus mouse T helper cell subset differentiation.
  • To explore the molecular basis for species-specific effects of type I IFNs on Th1 immune responses.
  • To discuss the implications of IFN-beta treatment for multiple sclerosis (MS) and the Th1/Th2 paradigm in MS.

Main Methods:

  • Literature review of recent scientific data.
  • Analysis of molecular mechanisms underlying IFN-mediated T cell differentiation.

Related Experiment Videos

  • Discussion of clinical relevance in the context of multiple sclerosis treatment.

    • Main Results:

    • Type I IFNs exhibit species-specific effects, differentially inducing Th1 immune responses in humans and mice.
    • The molecular basis for these species-specific effects is elucidated.
    • The Th1/Th2 paradigm's value in understanding MS pathogenesis and treatment is critically examined.

    Conclusions:

    • IFNs play a critical, species-specific role in T helper cell differentiation.
    • Understanding these differences is vital for interpreting research and developing treatments, particularly for autoimmune diseases like MS.
    • The Th1/Th2 framework remains relevant but requires nuanced application in complex diseases like MS.