Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PHMPL: a computer program for hazard estimation using a penalized likelihood method with interval-censored and

P Joly1, L Letenneur, A Alioum

  • 1ISPED, Université Victor Segalen Bordeaux II, France. pierre.joly@dim.u-bordeaux2.fr

Computer Methods and Programs in Biomedicine
|December 1, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for RNA integrity in fresh-frozen renal cancer samples from routine practice (UroCCR 9).

The French journal of urology·2026
Same author

Letter to the Editor: The French Model of Senior Housing to Tackle Housing Inequalities.

The Journal of frailty & aging·2024
Same author

Ten Years after the National Alzheimer's Plan: Dementia Remains a Hidden Syndrome in France.

The journal of prevention of Alzheimer's disease·2023
Same author

Co-Occurrence of Geriatric Syndromes and Diseases in the General Population: Assessment of the Dimensions of Aging.

The journal of nutrition, health & aging·2022
Same author

Older People Facing the Crisis of COVID-19: Between Fragility and Resilience.

The Journal of frailty & aging·2021
Same author

Ginkgo Biloba Extract Consumption and Long-Term Occurrence of Death and Dementia.

The journal of prevention of Alzheimer's disease·2017

This study introduces a new program for analyzing survival data with censoring and truncation. The method estimates the hazard function using penalized likelihood and splines, aiding dementia incidence research.

Area of Science:

  • Biostatistics
  • Survival Analysis
  • Epidemiology

Background:

  • The Cox model is standard for right-censored and truncated survival data.
  • Complex data structures require advanced analytical methods.

Purpose of the Study:

  • To propose a program for estimating hazard functions in proportional hazards models.
  • To handle complex observation schemes, including general censoring and left-truncation.
  • To provide confidence bands for the hazard function estimator.

Main Methods:

  • Non-parametric estimation of the hazard function by maximizing penalized likelihood.
  • Approximation of the solution using splines.
  • Selection of the smoothing parameter via approximate cross-validation.

Related Experiment Videos

Main Results:

  • A program is developed to estimate hazard functions for complex survival data.
  • The method provides confidence bands for the hazard estimator.
  • The approach was illustrated by estimating age-specific dementia incidence and a risk factor.

Conclusions:

  • The proposed method effectively estimates hazard functions in proportional hazards models with complex censoring and truncation.
  • The program facilitates the analysis of challenging survival datasets, such as dementia incidence.
  • This approach offers a robust tool for epidemiological and biostatistical research.