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Uric acid in hypertension and cardiovascular disease

M Alderman1

  • 1Albert Einstein College of Medicine, Bronx, NY, USA. alderman@aecom.yu.edu

The Canadian Journal of Cardiology
|December 1, 1999
PubMed

Insights

High uric acid levels are linked to increased heart problems in treated hypertension patients. Further research is needed to determine if uric acid causes these cardiac events or is merely associated.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Diseases

Background:

  • Cardiovascular disease is the leading cause of death globally, with hypertension as a major risk factor.
  • Current antihypertensive therapies offer incomplete cardioprotection, necessitating novel risk identification strategies.
  • Elevated uric acid is increasingly recognized as a potential risk marker in various conditions, including hypertension.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and cardiac morbidity and mortality in well-controlled hypertensive patients.
  • To determine if uric acid is an independent predictor of cardiac events beyond blood pressure reduction.

Main Methods:

  • Prospective study design.
  • Inclusion of a large cohort of well-controlled hypertensive subjects.
  • Analysis of the association between serum uric acid levels and cardiac events.

Main Results:

  • A strong, specific, stepwise, and independent association was found between increasing serum uric acid levels and cardiac morbidity and mortality.
  • This association persisted even in patients with effectively managed hypertension.

Conclusions:

  • Elevated serum uric acid is a significant predictor of cardiac events in treated hypertensive individuals.
  • Further investigation is required to elucidate the causal role of uric acid in the pathogenesis of cardiovascular disease.

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