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Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica
1Department of Marine Resources, National Sun Yat-sen University, Department of Microbiology, Kaohsiung Medical College, Department of Chemistry, and National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Journal of Natural Products
|December 2, 1999
Abstract:
Two new cytotoxic cembranoid diterpenes, brassicolide (1) and brassicolide acetate (2); a new cytotoxic sesquiterpene, (-)-4alpha-O-acetyl-selin-11-en (3); and six cytotoxic terpenoids, (-)-selin-11-en-4alpha-ol (4), 2-hydroxynephthenol (5), nephthenol (6), cembrene A (7), epoxycembrene A (8), and (-)-beta-elemene (9), have been isolated from the Formosan soft coral Nephthea brassica. The structures of compounds 1-9 were determined by spectral, chemical, and X-ray crystallographic analysis.