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Updated: Aug 31, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Signaling via vascular endothelial growth factor receptors
T V Petrova1, T Makinen, K Alitalo
1Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Abstract:
Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses. The review focuses on the signaling pathways that are initiated from these receptors and the recently identified VEGF coreceptor neuroplilin-1.
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