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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
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Related Experiment Video

Updated: Jul 19, 2026

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

The metastatic patterns of osteosarcoma.

G M Jeffree, C H Price, H A Sissons

    British Journal of Cancer
    |July 1, 1975
    PubMed
    Summary

    Osteosarcoma bone tumors frequently metastasize to the lungs. Extra-pulmonary metastases (EPM) are more common at autopsy than clinically, indicating widespread disease progression.

    Area of Science:

    • Oncology
    • Pathology
    • Skeletal System Neoplasms

    Background:

    • Osteosarcoma is a primary bone malignancy with a propensity for metastasis.
    • Understanding metastatic patterns is crucial for prognosis and treatment strategies.

    Purpose of the Study:

    • To compare the anatomical distribution and frequency of osteosarcoma metastases in clinical and autopsy series.
    • To analyze the behavior of long bone tumors versus those arising elsewhere.
    • To investigate factors influencing metastatic spread and survival.

    Main Methods:

    • Retrospective analysis of 152 clinical osteosarcoma cases with evident metastases.
    • Review of 43 autopsy cases of osteosarcoma.
    • Comparison of metastatic patterns based on tumor location (long bone vs. others).

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    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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    Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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    Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

    Published on: October 28, 2021

    Related Experiment Videos

    Last Updated: Jul 19, 2026

    Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
    07:44

    Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

    Published on: March 12, 2018

    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
    06:53

    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

    Published on: September 9, 2020

    Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
    04:25

    Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

    Published on: October 28, 2021

    Main Results:

    • Long bone osteosarcomas predominantly metastasize to the lungs (over 90% in fatal cases).
    • Extra-pulmonary metastases (EPM) significantly increase from clinical (33%) to autopsy (83%) findings.
    • Vertebrae and pelvis are common sites for EPM; muscle metastasis is rare.
    • Local recurrence correlates with increased osseous metastases.

    Conclusions:

    • Osteosarcoma exhibits extensive metastatic potential, often underestimated clinically.
    • The timing and location of metastases impact survival, with delayed appearance correlating to longer survival.
    • Radiotherapy as definitive treatment may increase local recurrence and subsequent metastases.