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Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643
M S Brown1, J P Dirlam, H A McArthur
1Pfizer Central Research, Groton, CT 06340, USA.
The Journal of Antibiotics
|December 2, 1999
Abstract:
Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.