Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase II trial of bevacizumab and rucaparib in recurrent carcinoma of the cervix or endometrium.

Gynecologic oncology·2022
Same author

Pulsatile hyperglycemia increases insulin secretion but not pancreatic β-cell mass in intrauterine growth-restricted fetal sheep.

Journal of developmental origins of health and disease·2018
Same author

Growth failure among preterm infants due to insufficient protein is not innocuous and must be prevented.

Journal of perinatology : official journal of the California Perinatal Association·2016
Same author

The extent of neurosis.

British medical journal·2010
Same author

The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination.

Osteoarthritis and cartilage·2009
Same author

Optimizing protein intake in preterm infants.

Journal of perinatology : official journal of the California Perinatal Association·2009

Related Experiment Video

Updated: Jul 16, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Small for gestational age: a new insight?

M R Stearns1, C G Jackson, J A Landauer

  • 1University of Colorado Medical School, Denver, USA.

Medical Hypotheses
|December 2, 1999
PubMed
Summary

Acidosis impairs nitric oxide (NO) production from L-arginine, potentially compromising vascular perfusion, growth, and tissue repair. This study compares acidemia

Area of Science:

  • Physiology
  • Biochemistry

Background:

  • Acidosis reduces nitric oxide synthase (NOS) activity, impairing nitric oxide (NO) generation from L-arginine (L-arg).
  • Compromised vascular perfusion, growth, and tissue repair can occur when NO production is reduced, even without overt acidemia.
  • L-arginine is a crucial amino acid for anabolic processes and vascular health.

Purpose of the Study:

  • To investigate the relationship between acidemia and nitric oxide (NO) production.
  • To compare the effects of severe and modest acidemia on the balance between acidemia and NO production.
  • To explore conditions like fetal growth restriction and microgravity-induced bone/muscle loss.

Main Methods:

  • Comparative analysis of two conditions with reported acidemia: intrauterine growth restriction and microgravity.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
06:43

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

Related Experiment Videos

Last Updated: Jul 16, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
06:43

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

  • Assessment of the interplay between acidemia severity and nitric oxide (NO) production.
  • Evaluation of L-arginine availability and its impact on NO synthesis.

    • Main Results:

    • Acidosis significantly inhibits the conversion of L-arginine to NO by NOS.
    • Reduced NO production due to acidosis can lead to compromised organ perfusion.
    • Both severe (fetal growth restriction) and modest (microgravity) acidemia impact the acid-base balance and NO homeostasis.

    Conclusions:

    • Maintaining adequate L-arginine levels and normal acid-base balance is critical for optimal NO production.
    • Disruptions in acid-base homeostasis, as seen in acidemia, can negatively affect vascular function and tissue repair.
    • Further research is needed to fully elucidate the mechanisms linking acidemia, L-arginine metabolism, and NO signaling in various physiological and pathological states.