Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk factors for developing brain herniation during diabetic ketoacidosis.

C P Mahoney1, B W Vlcek, M DelAguila

  • 1Department of Pediatric Endocrinology, Children's Hospital and Regional Medical Center, Seattle, Washington 98105, USA.

Pediatric Neurology
|December 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early development of the renal lesions in infantile cystinosis.

Pediatric nephrology (Berlin, Germany)·2000
Same author

Human insulin B chain but not A chain decreases the rate of diabetes in BB rats.

Diabetes research and clinical practice·2000
Same author

GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat.

Autoimmunity·1999
Same author

Growth hormone therapy of Turner's syndrome: beneficial effect on adult height.

The Journal of pediatrics·1998
Same author

Humoral hypercalcemia due to an occult renal adenoma.

Pediatric nephrology (Berlin, Germany)·1997
Same author

Cataplexy and monoamine oxidase deficiency in Norrie disease.

Neurology·1996

Diabetic ketoacidosis (DKA) in children can lead to brain herniation. Severe acidosis and rapid fluid rates increase risk, while controlled hydration prevents it.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Neurology

Background:

  • Diabetic ketoacidosis (DKA) is a serious complication of diabetes mellitus.
  • Brain herniation is a rare but severe complication of DKA treatment.
  • Identifying risk factors for brain herniation is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence and risk factors of brain herniation in children with DKA.
  • To evaluate the association between initial fluid resuscitation rates and brain herniation.
  • To determine optimal fluid management strategies to prevent DKA-related brain herniation.

Main Methods:

  • Retrospective chart review of children admitted with DKA over 12 years.
  • Analysis of clinical data including blood pH, PCO2, and initial fluid administration rates.

Related Experiment Videos

  • Comparison of brain herniation incidence based on acidosis severity and fluid therapy rates.

    • Main Results:

    • Nine out of 153 children experienced brain herniation.
    • Severe acidosis (pH < 7.1) and hypercapnia (PCO2 < 20 mm Hg) were significant risk factors.
    • Fluid administration exceeding 50 mL/kg in the first 4 hours was associated with increased brain herniation risk.

    Conclusions:

    • Maintaining adequate pH and PCO2 levels is vital in DKA management.
    • Aggressive initial fluid resuscitation ( > 50 mL/kg/4h) in severe DKA increases brain herniation risk.
    • Controlled fluid administration is recommended to mitigate DKA-related brain herniation.