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Updated: Jan 29, 2026

Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser
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Permanent implantation of 125I sources in the prostate: radical limits of simplicity
P W McLaughlin1, V Narayana, M T Fields
1Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, USA.
Purpose:
To determine the effect of reducing the number of sources per implantation on the dose coverage of the prostate volume.
Materials And Methods:
Idealized source distributions were planned for four, eight, 16, 24, 32, and 48 sources. The peripheral loading technique was used to plan a uniform, conformal dose distribution to the target volume, which was the prostate volume as visualized at ultrasonography. Source-placement error was estimated by using measured error magnitudes and was expressed with systematic and random components. The relative sensitivities of the plans to the source-placement error were studied.
Results:
Idealized planned target coverage can be adequately achieved with comparable dose distributions with eight or more sources. The sensitivity to source-placement error is comparable for plans with 16 or more sources.
Conclusion:
It is theoretically possible to radically simplify implantation without compromising target coverage or error tolerance.
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