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[Comparative study of HLA-DRB1 allele in patients with chronic bronchitis and bronchial asthma]
1Department of Respiratory Diseases, The Second Hospital of Shanxi Medical University, Taiyuan 030001 P.R.China. Wangchonggang@263.net
Objective:
To make a comparative study of HLA-DRB1 allele frequencies in the cases of chronic bronchitis and bronchial asthma.
Methods:
The authors investigated 74 patients with chronic bronchitis and 64 patients with bronchial asthma from among the Han people in Shanxi province. PCR/SSP technique was used for HLA-DRB1 typing, and the patients' data were compared with the normal controls'.
Results:
The frequency of HLA-DRB1*1201/1202(24.32%) was significantly increased in the chronic bronchitis group(P<0.01),and the frequency of HLA-DRB1*1501/1502(23.44%) was significantly increased in the bronchial asthma group(P<0.05). The frequencies of other DRB1 alleles were not significantly increased in these groups.
Conclusion:
The results indicate that HLA-DRB1*1201/1202 allele is associated with chronic bronchitis and HLA-DRB1*1501/1502 allele is associated with bronchial asthma in the patients among the Hans in Shanxi province.