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Updated: Aug 8, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Increased cerebrospinal fluid protein tau concentration in neuro-AIDS
L Andersson1, K Blennow, D Fuchs
1Institute of Internal Medicine, Department of Infectious Diseases, Göteborg University, Sahlgrenska University Hospital, S-416 85, Göteborg, Sweden. lars-magnus.andersson@medfak.gu.se
Objectives:
Assessment of cerebrospinal fluid (CSF) levels of protein tau in human immunodeficiency virus type 1 (HIV-1) infection.
Material And Methods:
CSF tau levels were analyzed in 52 HIV-1-infected patients, 37 of whom had no neurological symptoms, eight had aquired immunodeficiency syndrome (AIDS) dementia complex (ADC), and seven had AIDS with other neurological complications.
Results:
A significantly higher mean CSF tau concentration was found in patients with ADC (380 pg/ml) compared with patients with neuroasymptomatic HIV-1 infection (120 pg/ml, P<0.01) and HIV-negative controls (150 pg/ml, P<0.05). No difference in CSF tau levels was found between patients with ADC and patients with AIDS with other neurological complications.
Conclusion:
CSF tau might be used as a biochemical marker for axonal degeneration and might be of use to identify HIV-1-infected patients with ADC and other neurological complications, but it cannot discriminate between ADC and other neurological complications in HIV-1-infection.
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