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Development and evaluation of a multiple-unit oral sustained release dosage form for S(+)-ibuprofen: preparation and
P J Cox1, K A Khan, D L Munday
1School of Pharmacy, The Robert Gordon University, Aberdeen, UK.
International Journal of Pharmaceutics
|December 3, 1999
Abstract:
Mini-matrix tablets containing S(+)-ibuprofen have been prepared by the wet granulation method. The hydrophilic matrix was formed with either xanthan gum, karaya gum or hydroxymethylcellulose (HPMC) together with a choice of additives from lactose, Encompress(R), Avicel(R) PH101, talc and Lubritab(R). Multiple unit dosage forms (MUDFs) were subsequently obtained by encapsulating the mini-matrix tablets into hard gelatin capsules. Preparation, in vitro release profiles and release kinetics are presented.