Evidence for a unique N-linked glycan associated with human infertility on sperm CD52: a candidate contraceptive

¹University of Virginia Health Sciences Center, Center for Recombinant Gamete Contraceptive Vaccinogens, Department of Cell Biology, Charlottesville, USA.

|December 3, 1999

Abstract:

A major objective in developing a sperm antigen-based contraceptive vaccine for humans is the discovery of sperm surface immunogens that are functionally relevant and sperm specific. The latter criterion is deemed essential to avoid the possibility of inducing autoimmune disease upon vaccination. This review presents evidence that a unique carbohydrate epitope is synthesized in the human epididymis, is attached to the core peptide of CD52, a lymphocyte differentiation marker, and is subsequently inserted into the sperm membrane via a glycosylphosphatidylinositol anchor. This unique CD52 glycoform is localized to the entire sperm surface, functions as a potent target for agglutinating and cytotoxic antibodies, and is one of the few well-defined sperm surface glycoproteins indicated in human antibody-mediated infertility.

Related Experiment Videos

Evidence for a unique N-linked glycan associated with human infertility on sperm CD52: a candidate contraceptive

Related Concept Videos

Postharvest Storage Losses Associated with Rhizomania in Sugar Beet.

Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form.

Conditioned medium from spinal cord cells stimulates DRG cells to migrate, cluster and rearrange in dissociated cell cultures.

Proteomic identification of galectin-3 binding ligands and characterization of galectin-3 proteolytic cleavage in human prostasomes.

Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice.

SpermCheck Fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia.

Entering the Age of Specificity in T Cell Immunity.

Beta Cell Stress to Epitope Diversification: Post-Translationally Modified Antigens in Type 1 Diabetes.

Human IgD+IgM- Memory B Cells and Their Possible Impact on Mucosal Homeostasis and Tolerance.

Building an Interleukin-10-Producing Identity: How B Cells Acquire Interleukin-10 Competence and How Plasma Cell Differentiation Consolidates This Program.

Discovery of Post-Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat.

BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity.

UPF1-dependent glycolysis driven by LINC00887 facilitates macrophage M2 polarization in clear cell renal cell carcinoma.

Phenotypic clustering of atrial fibrillation patients using latent class analysis and its potential utility for ablation strategy: insights from the DIRECT-Extend and EARNEST-PVI studies.

Clinical Evaluation of Polyglycolic Acid Sheet Application After Partial Glossectomy: A Retrospective Analysis of 284 Consecutive Cases.

NONO modulates tumorigenesis and metastatic potential of lung squamous cell carcinoma.

Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic submucosal dissection: a multicenter cohort study integrating overall risk prediction and timing of recurrence.

Interpretable machine learning models for predicting New-onset acute organ injury within 48 hours of admission in patients with community-acquired acute cholangitis.

Related Experiment Videos

Evidence for a unique N-linked glycan associated with human infertility on sperm CD52: a candidate contraceptive...

Abstract:

Related Concept Videos

Related Articles

Evidence for a unique N-linked glycan associated with human infertility on sperm CD52: a candidate contraceptive