Data on the PCR Turkish population based loci: LDLR, GYPA, HBGG, D7S8, and Gc

Area of Science:

• Forensic genetics
• Population genetics
• Human genetics

Background:

• Understanding genetic diversity within populations is crucial for forensic and anthropological studies.
• Population-specific genetic data aids in accurate interpretation of forensic evidence.
• Previous studies have established genetic profiles for various global populations.

Purpose of the Study:

• To determine allele and genotype frequencies for five specific PCR-based genetic loci in an unrelated Turkish population.
• To assess the genetic structure of the Turkish population by comparing it with US Caucasian and African American populations.
• To evaluate compliance with Hardy-Weinberg Equilibrium (HWE) for these loci in the studied Turkish cohort.

Main Methods:

• Analysis of allele and genotype frequencies using five PCR-based genetic markers (LDLR, GYPA, HBGG, D7S8, Gc).
• Statistical analysis including chi-square and exact tests to compare observed genotype distributions with HWE.
• Comparative analysis of Turkish genotype frequencies against published data from US African American and US Caucasian populations.

Main Results:

• Genotype distributions at LDLR, GYPA, D7S8, and Gc loci were in HWE in the Turkish population.
• The HBGG locus genotype distribution deviated significantly from HWE in the Turkish population.
• Significant genetic differences were observed between the Turkish population and US Caucasian (at HBGG) and US African American (at LDLR, HBGG, Gc) populations.

Conclusions:

• The HBGG locus exhibits non-equilibrium in the Turkish population, suggesting potential evolutionary or demographic influences.
• The genetic profiles of the Turkish population differ notably from US Caucasian and African American populations at specific loci.
• This study provides valuable population-specific genetic data for the Turkish population, enhancing forensic and anthropological applications.