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Related Experiment Videos

Brain tumor masquerading as stroke.

L B Morgenstern1, R F Frankowski

  • 1Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA. Imorgens@neuro.med.uth.tmc.edu

Journal of Neuro-Oncology
|December 3, 1999
PubMed
Summary
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Differentiating brain tumors from stroke in acute neurological cases remains challenging. Misdiagnosis rates persist even in the computed tomography (CT) era, highlighting a need for improved diagnostic strategies.

Area of Science:

  • Neurology
  • Oncology
  • Radiology

Background:

  • Accurate diagnosis of acute focal neurologic deficits is critical to prevent treatment delays or errors.
  • Historically, 3% of brain tumor patients were misdiagnosed as stroke before computed tomography (CT).
  • This study investigates if CT has improved the diagnostic accuracy for brain tumors presenting as stroke.

Observation:

  • A review of 224 brain tumor patients at Johns Hopkins Hospital was conducted.
  • Eleven patients (4.9%) were initially misdiagnosed as stroke.
  • Misdiagnosed patients were older and more likely to have Glioblastoma Multiforme.

Findings:

  • The misdiagnosis rate of brain tumor as stroke was 4.9% in the CT era.
  • Older age and Glioblastoma Multiforme were associated with initial misdiagnosis.

Related Experiment Videos

  • 82% of misdiagnosed patients had no prior cancer history, versus 59% of correctly diagnosed patients.

    • Implications:

    • Distinguishing acute brain tumors from stroke remains a significant diagnostic challenge.
    • Computed tomography (CT) may not be sufficient to rule out brain tumors in acute neurological deficits.
    • Further prospective studies are needed to validate these findings and improve diagnostic protocols.