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Related Experiment Videos

Lupine-induced anaphylaxis.

V Matheu1, M de Barrio, Z Sierra

  • 1Allergy Section, Gregorio Marañón University General Hospital, Madrid, Spain. vmatheud@meditex.es

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 3, 1999
PubMed
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This study details a lupine-sensitized patient experiencing anaphylaxis, revealing in vitro cross-reactivity with other legumes. Clinical cross-reactivity evolved over time, highlighting complexities in legume allergy diagnosis.

Area of Science:

  • Allergy and Immunology
  • Food Hypersensitivity Research
  • Clinical Diagnostics

Background:

  • Legumes are common allergens in children and adults.
  • While cross-reacting antibodies are frequent, clinical cross-reactivity is rare.
  • Understanding legume allergy is crucial for public health.

Observation:

  • A case of lupine-induced anaphylaxis was reported.
  • Skin prick tests (SPT), IgE testing, and oral challenges were performed.
  • In vivo and in vitro cross-reactivity with other legumes was investigated.

Findings:

  • Type-I hypersensitivity reactions were observed with lupine and other legumes.
  • Discrepancies noted between in vitro peanut allergy tests and clinical tolerance.
  • Partial cross-reactivity demonstrated via ELISA and immunoblotting inhibition.

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Implications:

  • Lupine sensitization can lead to significant allergic reactions.
  • Clinical cross-reactivity can develop over time, complicating diagnosis.
  • Further research is needed to understand variability in legume allergy cross-reactivity.