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Related Experiment Videos

Extrusion of testosterone pellets: a randomized controlled clinical study.

S Kelleher1, L Turner, C Howe

  • 1Andrology Unit, Royal Prince Alfred Hospital &, Department of Medicine, University of Sydney, Australia.

Clinical Endocrinology
|December 3, 1999
PubMed
Summary

Washing testosterone pellets before implantation does not reduce the rate of pellet extrusion. This study found no significant difference in extrusion rates between washed and unwashed pellets in men undergoing androgen replacement therapy.

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Area of Science:

  • Endocrinology
  • Urology
  • Androgen Replacement Therapy

Background:

  • Testosterone implantation is an effective androgen replacement therapy.
  • Pellet extrusion is the most frequent side-effect of testosterone implantation.
  • This study aimed to reduce testosterone pellet extrusion rates.

Purpose of the Study:

  • To determine if washing testosterone pellets decreases extrusion rates.
  • Investigate the efficacy of pellet washing in reducing side-effects.
  • Evaluate the impact of pellet preparation on implantation outcomes.

Main Methods:

  • Prospective, randomized parallel group design.
  • 251 testosterone implantation procedures in men with androgen deficiency.
  • Comparison of washed versus unwashed testosterone pellets.

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Main Results:

  • The extrusion rate was 12% in the wash group and 11.1% in the control group.
  • No significant difference in extrusion rates between washed and unwashed pellets.
  • No evidence of benefit in secondary endpoints like adverse events, bleeding, or infection.

Conclusions:

  • Pellet washing does not reduce the subsequent extrusion rate.
  • The procedure did not decrease adverse events associated with testosterone implantation.
  • Higher adverse event rates in this study may be due to rigorous follow-up.