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High serum laminin concentrations in patients with Candida sepsis
E Presterl1, A Lassnigg, P Mueller-Uri
1University of Vienna, Vienna, Austria Elisabeth.Presterla@akh-wien.ac.at
Background:
Laminin, a major component of the basement membrane, plays a critical role in normal cell adhesion and also during tissue invasion of pathogenic microorganisms.
Materials And Methods:
Serum laminin concentrations were determined in 19 patients with Candida albicans sepsis, in 13 patients with bacterial sepsis and in 20 noninfectious controls.
Results:
Serum laminin concentrations of both, patients with candidal and bacterial sepsis, were significantly elevated compared to the controls (486 ng mL-1 [155-924], median [range]; P < 0.01). Laminin concentrations were significantly higher in patients with Candida sepsis than in patients with bacterial sepsis on day 1 (2565 ng mL-1 [659-6064] vs. 994 ng mL-1 [386-2064]; P < 0.01), day 7 (1594 ng mL-1 [607-4611] vs. 684 ng mL-1 [284-1920]; P < 0.05) and day 14 (1444 ng mL-1 [202-2131] vs. 386 ng mL-1 [180-1658]; P < 0.05).
Conclusions:
Laminin serum concentrations might be useful to differentiate nonbacterial, bacterial and fungal etiology.