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Updated: Jul 30, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
Published on: June 7, 2017
Organogenic role of B lymphocytes in mucosal immunity
T V Golovkina1, M Shlomchik, L Hannum
1Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Abstract:
Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.
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