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["Evanescent" prostate carcinoma].

J A Ortiz Rey1, E A Da Silva, I Antón Badiola

  • 1Servicio de Anatomía Patológica, Centro Médico POVISA, Vigo, Pontevedra.

Actas Urologicas Espanolas
|December 10, 1999
PubMed
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The evanescent cancer phenomenon (ECP) is a rare finding in prostatectomy specimens. It may be caused by hormonal blockade reducing tumor size or by early detection of insignificant tumors through screening.

Area of Science:

  • Urology
  • Pathology
  • Oncology

Background:

  • Prostatectomy specimens increasingly show minimal or no tumor volume despite preoperative diagnosis of adenocarcinoma via needle biopsy.
  • This phenomenon is termed the evanescent cancer phenomenon (ECP).

Observation:

  • A review of 145 prostatectomies (1988-1997) identified 3 cases (2%) of ECP.
  • ECP occurrence differs between patients receiving preoperative hormonal blockade and those who do not.

Findings:

  • In patients with hormonal blockade, ECP occurs in <5% of prostatectomies, likely due to tumor volume reduction and microscopic changes.
  • In patients without hormonal treatment, ECP is rare and may result from screening detecting small, potentially insignificant tumors, which are then completely ablated by biopsy or missed due to technical limitations.

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Implications:

  • Understanding ECP is crucial for accurate prostate cancer diagnosis and treatment planning.
  • Further research is needed to differentiate between true tumor ablation and diagnostic limitations in ECP cases.
  • This phenomenon highlights the complexities of prostate cancer detection and the impact of treatment on histopathological findings.