[Effects of low-dose FP therapy for advanced gastric cancer cases]

The clinical application of low-dose FP therapy has spread rapidly in Japan. We examined the effects of this form of chemotherapy on patients with advanced gastric carcinoma in China. One cycle of this therapy consisted of intermittent infusion of CDDP (10 mg/body/3 hr), followed by intermittent infusion of 5-FU (250 mg/body/6 hr) and suppository administration of tegafur (500 mg) at night for 5 days with 2-day intervals. As a result, a partial response for the primary lesion and lymph nodes was obtained in some cases, 2 of which are described in this paper. No serious side effects were noted, although administration continued over a long period. Our results suggest that neoadjuvant chemotherapy with low-dose FP may be useful as an inductive approach for advanced gastric cancer, and that the regimen can become a standard therapy for gastric cancer.