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Olanzapine increases weight and serum triglyceride levels
D N Osser1, D M Najarian, R L Dufresne
1Harvard Medical School at Taunton State Hospital, Mass 02780, USA.
The Journal of Clinical Psychiatry
|December 10, 1999
Summary
Olanzapine use significantly increased patient weight and fasting triglyceride levels over 12 weeks, with weight gain strongly associated with triglyceride elevation. These findings highlight potential metabolic risks associated with olanzapine treatment.
Area of Science:
- Psychiatry
- Pharmacology
- Metabolic Medicine
Background:
- Clozapine is linked to weight gain and elevated triglycerides.
- Pharmacologic similarities exist between clozapine and olanzapine.
- The study investigated olanzapine's impact on triglyceride levels.
Purpose of the Study:
- To assess the effect of olanzapine on patient weight and serum triglyceride levels.
- To determine if olanzapine use is associated with increased triglycerides.
- To explore the relationship between weight change and triglyceride changes.
Main Methods:
- Prospective tracking of 25 inpatients treated with olanzapine.
- Measurement of weight and fasting triglyceride levels before and after 12 weeks of treatment.
- Statistical analysis to determine significance and associations.
Main Results:
- Mean weight increased by 12 lb (5.4 kg) after 12 weeks of olanzapine.
- Mean fasting triglycerides increased by 60 mg/dL (p < .05).
- A strong association was found between weight change and triglyceride increase (p < .02).
Conclusions:
- Olanzapine significantly impacts patient weight and serum triglyceride levels.
- Weight gain appears to be a key factor in olanzapine-induced triglyceride elevation.
- Clinical monitoring for metabolic changes is recommended for patients on olanzapine.