Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A dose-outcome analysis of risperidone.

R C Love1, R R Conley, D L Kelly

  • 1Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, USA.

The Journal of Clinical Psychiatry
|December 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical Activity Compliance to American Cancer Society Recommendations Amongst Hematopoietic Stem Cell Transplant Survivors.

Hematology/oncology and stem cell therapy·2023
Same author

Oxytocin and sexual function in males and females with schizophrenia.

Schizophrenia research·2018
Same author

CLIMATE ECONOMICS. Opportunities for advances in climate change economics.

Science (New York, N.Y.)·2016
Same author

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin.

Oncogenesis·2014
Same author

Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia.

Molecular psychiatry·2014
Same author

Treatment of the special patient with schizophrenia.

Dialogues in clinical neuroscience·2011
Same journal

Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

The Journal of clinical psychiatry·2026
Same journal

Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

The Journal of clinical psychiatry·2026
Same journal

Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

The Journal of clinical psychiatry·2026
Same journal

Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

The Journal of clinical psychiatry·2026
Same journal

Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

The Journal of clinical psychiatry·2026
Same journal

The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

The Journal of clinical psychiatry·2026
See all related articles

Lower risperidone doses (2-4 mg/day) improve patient discharge rates compared to higher doses (6 mg/day). This suggests initial dosing recommendations may be excessive for effective antipsychotic treatment.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Therapeutics

Background:

  • Antipsychotic dosing is crucial for treatment outcomes, yet challenges persist.
  • Current risperidone dosing guidelines may recommend excessively high initial doses.
  • This study investigates risperidone dosage trends and their impact on patient discharge.

Purpose of the Study:

  • To analyze risperidone dosage trends in psychiatric facilities.
  • To determine the relationship between risperidone dose and patient discharge rates.
  • To evaluate the efficacy of different risperidone dosage ranges on treatment outcomes.

Main Methods:

  • Retrospective analysis of 1056 patients treated with risperidone in Maryland state psychiatric facilities (1994-1997).
  • Kaplan-Meier survival analysis used to measure discharge rates and time to discharge.

Related Experiment Videos

  • Comparison of discharge rates across different risperidone dosage groups (2 mg, 4 mg, 6 mg).

    • Main Results:

    • Mean risperidone doses have declined as its use increased.
    • Discharged patients received significantly lower risperidone doses than those remaining hospitalized.
    • Patients on 2 mg and 4 mg/day risperidone showed significantly higher discharge rates than those on 6 mg/day.

    Conclusions:

    • Lower risperidone doses (2-4 mg/day) are associated with better patient discharge outcomes.
    • Initial dosing recommendations of 6 mg/day for risperidone may be too high.
    • Clinicians should consider trials of lower risperidone doses before escalating to higher amounts.