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Related Experiment Videos

Neuropathy target esterase.

P Glynn1

  • 1MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, U.K. pg8@le.ac.uk

The Biochemical Journal
|December 10, 1999
PubMed
Summary
This summary is machine-generated.

Neuropathy target esterase (NTE) is a neuron-associated protein. Organophosphates targeting NTE cause delayed neuropathy, suggesting a toxic gain of function.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Cell Biology

Background:

  • Neuropathy target esterase (NTE) is an integral membrane protein in vertebrate neurons.
  • NTE plays a role in cell-signalling pathways governing neuron-glia interactions during nervous system development.
  • Its physiological substrate remains unidentified, despite its known serine esterase activity.

Purpose of the Study:

  • To investigate the structure and function of Neuropathy target esterase (NTE).
  • To understand the mechanism by which organophosphates induce neuropathy via NTE.
  • To explore the potential toxic gain of function in NTE.

Main Methods:

  • Sequence analysis to determine NTE's relationship to other esterases.
  • Characterization of NTE's functional domains (N-terminal regulatory, C-terminal effector).

Related Experiment Videos

  • Biochemical assays of recombinant NTE domains in phospholipid liposomes.

    • Main Results:

    • NTE is evolutionarily distinct from known serine hydrolases.
    • The C-terminal effector domain, containing esterase activity and transmembrane segments, is conserved across species.
    • Recombinant NTE domain exhibits phenyl valerate hydrolase activity within liposomes.
    • Organophosphate-induced neuropathy involves covalent attachment to NTE's active site serine.

    Conclusions:

    • NTE possesses unique structural and functional characteristics.
    • The esterase activity of NTE is implicated in organophosphate-induced delayed neuropathy.
    • A toxic gain of function in NTE is proposed as the mechanism for neuropathy.