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Updated: Oct 18, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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[Cellular signaling in response to TGFbeta: the paradox of a factor that blocks cell proliferation and enhances

M L Vignais1

  • 1IGMM/CNRS UMR 5535, 1919, route de Mende, 34293 Montpellier Cedex 5.

Bulletin Du Cancer
|December 10, 1999
PubMed

Insights

Transforming growth factor beta (TGFbeta) initially repressed cell growth but now shows it promotes extracellular matrix development and tumor metastasis. Understanding TGFbeta signaling offers new cancer therapy targets.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Context:

  • Transforming growth factor beta (TGFbeta) was initially recognized for its role in inhibiting cellular proliferation.
  • Recent research reveals TGFbeta also significantly enhances extracellular matrix development and promotes tumor metastasis.
  • TGFbeta signaling is crucial in diverse biological processes including development, cell proliferation, and immune responses.

Purpose:

  • To elucidate the complex signaling mechanisms of TGFbeta, focusing on the role of SMAD proteins.
  • To explore the dual functions of TGFbeta in regulating cell proliferation and inducing metastasis.
  • To identify TGFbeta signaling as a potential therapeutic target for cancer treatment.

Summary:

  • TGFbeta signaling, mediated by SMAD proteins, regulates gene transcription from the cell membrane to the nucleus.
  • Activation of SMADs involves serine phosphorylations by TGFbeta receptors, with other SMADs providing feedback regulation.
  • Intricate regulation, including tissue specificity and pathway synergy, explains TGFbeta's diverse biological roles.

Impact:

  • The dual role of TGFbeta in cell proliferation and metastasis presents new therapeutic avenues.
  • Targeting TGFbeta signaling pathways could lead to novel cancer treatment strategies.
  • Further understanding of TGFbeta's complex regulatory network is essential for developing effective therapies.

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