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Distal hereditary motor neuronopathy of the Jerash type
L T Middleton1, K Christodoulou, A Mubaidin
1Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. ltmiddle@mdrtc.cing.ac.cy
Annals of the New York Academy of Sciences
|December 10, 1999
Abstract:
A novel form of autosomal recessive distal hereditary motor neuronopathy (distal HMN) is reported. The presence of pyramidal signs within the early stages of the disease with persistence of knee hyperreflexia form distinctive clinical features. We have mapped the HMN-J gene to chromosome 9p21.1-p12, within an estimated interval of 1.2-Mb.