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Related Experiment Videos

Hippocampal auditory gating in the hyperactive mocha mouse.

C L Miller1, M Burmeister, K E Stevens

  • 1Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA. clmiller@welchlink.welch.jhu.edu

Neuroscience Letters
|December 10, 1999
PubMed
Summary
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The mocha mouse mutants, resulting from AP-3 delta gene mutations, show neurological issues including hyperactivity and altered hippocampal function. Auditory evoked potentials reveal an enhanced response to paired tones in these mice.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurobiology

Background:

  • The mouse mutants mocha (mh) and mocha2J (mh2J) carry independent mutations in the AP-3 delta gene.
  • These mutants display neurological abnormalities, including hyperactivity, epileptiform electroencephalogram (EEG) patterns, and hippocampal dysfunction.

Purpose of the Study:

  • To investigate the neurological phenotype of mocha and mocha2J mouse mutants.
  • To analyze hippocampal function and auditory evoked potentials in AP-3 delta deficient mice.

Main Methods:

  • Utilizing depth electrode recordings to measure hippocampal auditory evoked potentials.
  • Comparing evoked potentials in mocha and mocha2J mutants with their littermate controls.
  • Observing EEG patterns under chloral hydrate anesthesia.

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Main Results:

  • A significant enhancement in the response to the first of two paired tones was observed in mocha and mocha2J mice compared to controls.
  • The characteristic theta rhythm seen in unanesthetized mocha mice was absent in anesthetized subjects.
  • Frequent spike discharge activity was noted in the recordings of anesthetized mocha and mocha2J mice.

Conclusions:

  • Mutations in the AP-3 delta gene lead to significant alterations in hippocampal auditory processing.
  • These findings highlight the role of AP-3 delta in neurological function and synaptic plasticity.
  • The study provides insights into the neurobiological underpinnings of the mocha mouse phenotype.