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Related Experiment Videos

Structure of the human uvula.

K Olofsson1, C Mattsson, M L Hammarström

  • 1Department of Otorhinolaryngology, University Hospital of Umeå, Umeå University, Sweden. katarina.olofsson@climi.umu.se

Acta Oto-Laryngologica
|December 10, 1999
PubMed
Summary

This study examined uvular tissue morphology, mast cells, and hyaluronan distribution. Findings reveal connective tissue and mast cell patterns supporting uvular mechanical resistance and susceptibility to edema and fibrosis.

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Area of Science:

  • Histology
  • Immunohistochemistry
  • Oral Biology

Background:

  • The uvula's unique structure and cellular components are not fully understood.
  • Investigating mast cells and hyaluronan distribution is crucial for understanding uvular function.

Purpose of the Study:

  • To investigate the morphology of uvular biopsies.
  • To determine the presence and distribution of mast cells.
  • To analyze the distribution of hyaluronan and its ligand CD44 within the uvula.

Main Methods:

  • Analysis of eleven uvular biopsies.
  • Examination of three microanatomical sites: surface epithelium, subepithelial area, and gland area.
  • Histological staining for morphology, mast cells, hyaluronan, and CD44.

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Main Results:

  • The uvula's surface epithelium is keratinized/parakeratinized, anchored by connective tissue papillae.
  • Increased intercellular space width in the epithelium near the basal lamina showed intense hyaluronan and CD44 staining.
  • Mast cells were concentrated near blood vessels and in connective tissue septa, correlating with high hyaluronan staining.

Conclusions:

  • The distribution of connective tissue and mast cells in the uvula supports its mechanical resilience.
  • The observed patterns suggest the uvula's capacity to undergo edema and fibrosis.