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Injection site eosinophilic granulomas and collagenolysis in 3 horses
N M Slovis1, J L Watson, V K Affolter
1Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, USA.
Journal of Veterinary Internal Medicine
|December 10, 1999
Summary
Hypersensitivity to silicone needle coatings caused raised nodules in horses. Histopathology revealed equine eosinophilic granuloma, suggesting an immune response to silicone in hypodermic needles.
Area of Science:
- Veterinary Dermatology
- Equine Pathology
- Immunology
Background:
- Standard hypodermic needles are coated with silicone to facilitate smooth insertion.
- Cutaneous nodules have been observed in horses following injections.
Observation:
- Three horses developed raised nodules within 48 hours post-injection with silicone-coated needles.
- Histopathological evaluation of nodules confirmed equine eosinophilic granuloma.
Findings:
- Experimental injections with coated needles induced severe eosinophilic granulomatous inflammation.
- Non-coated needles did not produce similar inflammatory reactions.
Implications:
- Silicone-based needle coatings may trigger hypersensitivity reactions in horses.
- This finding suggests a need to reconsider materials used in veterinary injection equipment.