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Related Experiment Videos

Biodegradable implants from poly-(alpha-hydroxy acid) polymers for isoniazid delivery.

L Hurley1, B R Andersen

  • 1West Side VA Medical Center and the University of Illinois College of Medicine, Chicago, USA.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 10, 1999
PubMed
Summary

This study developed a biodegradable polymer implant for sustained isoniazid (INH) delivery, showing it releases the tuberculosis drug for at least 15 weeks in animal models.

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Area of Science:

  • Biomaterials Science
  • Pharmacology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Effective drug delivery systems are crucial for improving treatment adherence and efficacy.
  • Long-acting formulations can overcome challenges associated with daily medication regimens.

Purpose of the Study:

  • To develop a novel subcutaneous polymer implant for sustained release of isoniazid (INH).
  • To evaluate the in vitro and in vivo performance of biodegradable poly-(alpha-hydroxy acid) implants for TB treatment.
  • To determine optimal parameters for implant fabrication and drug loading.

Main Methods:

  • In vitro assessment of drug release kinetics and implant structural stability in an aqueous environment.

Related Experiment Videos

  • In vivo studies in rabbits and baboons to measure serum and urine isoniazid levels over time.
  • Evaluation of factors influencing implant suitability, including polymer properties, particle sizes, drug loading, and press conditions.

    • Main Results:

    • Optimal implant characteristics were identified, including specific polymer types (100% L-lactide), particle sizes (<75 micron for polymer, 126-180 micron for INH), drug loading (≤46%), and press conditions (70°C, 345000 kPa).
    • Subcutaneous implants demonstrated sustained INH release in animal models for 15 to 26 weeks.
    • The developed polymer implant was structurally stable in aqueous conditions.

    Conclusions:

    • A structurally stable, long-acting isoniazid-releasing polymer implant was successfully developed.
    • The implant demonstrated sustained drug release over a minimum of 15 weeks.
    • Further studies in infected animals are required to establish optimal dosing for prophylaxis and treatment of active tuberculosis.