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[Hypertransaminasemia in an adolescent].

M Monfort-Gouraud1, A Hamza, K Nacer

  • 1Service de pédiatrie, centre hospitalier de Coulommiers, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|December 10, 1999
PubMed
Summary
This summary is machine-generated.

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A rare condition called macro-aspartate aminotransferase, a benign enzyme variant, can cause elevated serum levels. Awareness is key for clinicians to prevent unnecessary medical procedures for patients.

Area of Science:

  • Clinical Biochemistry
  • Enzymology

Background:

  • Elevated serum enzyme levels can indicate various health issues.
  • Diagnostic challenges arise from unusual enzyme variants.

Observation:

  • An adolescent presented with elevated serum aspartate aminotransferase (AST) levels.
  • Further testing revealed the elevation was due to macro-aspartate aminotransferase, an enzyme complex.

Findings:

  • Macro-aspartate aminotransferase is a persistent, benign phenomenon.
  • It is often an immunoglobulin G-complexed enzyme, leading to falsely high AST readings.

Implications:

  • Clinicians must be aware of macroenzymes to avoid misdiagnosis and unnecessary interventions.
  • Proper patient identification and record-keeping are crucial for managing this benign condition.

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