Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic veno-occlusive disease.

P Ribaud1, E Gluckman

  • 1Federation d'Hematologie, Service de Greffe de Moelle, Hôpital St Louis, Paris, France. patricia.ribaud@chu-stlouis.fr

Pediatric Transplantation
|December 10, 1999
PubMed
Summary

Hepatic veno-occlusive disease (VOD) is a complication following stem cell transplants, often linked to conditioning regimens. While diagnosis has improved, enhanced prophylaxis and treatment strategies for VOD remain critical.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis.

Annals of the rheumatic diseases·2007
Same author

Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis.

Annals of the rheumatic diseases·2007
Same author

Long-term outcomes after allogeneic stem cell transplantation for children with hematological malignancies.

Bone marrow transplantation·2007
Same author

Combined inhaled steroids and bronchodilatators in obstructive airway disease after allogeneic stem cell transplantation.

Bone marrow transplantation·2007
Same author

Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation.

Bone marrow transplantation·2007
Same author

[Clinical research at the European LeukemiaNet].

Deutsche medizinische Wochenschrift (1946)·2006

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Hepatology

Background:

  • Hepatic veno-occlusive disease (VOD) is a significant complication post-stem cell transplantation.
  • It is primarily a toxic effect of the conditioning regimen, potentially exacerbated by allogeneic reactions.
  • The condition affects both adult and pediatric populations with a reported mortality rate under 4%.

Purpose of the Study:

  • To summarize the current understanding of Hepatic Veno-occlusive Disease (VOD) following stem cell transplantation.
  • To highlight recent advancements in the diagnosis of VOD.
  • To emphasize the ongoing need for improved prophylactic and therapeutic strategies for VOD.

Main Methods:

  • Literature review on Hepatic Veno-occlusive Disease (VOD) in stem cell transplantation.
  • Analysis of diagnostic advancements and current treatment modalities.
  • Synthesis of information regarding prophylaxis and management.

Main Results:

  • Hepatic Veno-occlusive Disease (VOD) is a recognized toxicity of conditioning regimens in stem cell transplantation.
  • Recent progress has been made in diagnosing VOD.
  • The overall mortality rate for VOD is low (<4%), but significant challenges in prevention and treatment persist.

Conclusions:

  • Despite diagnostic improvements, Hepatic Veno-occlusive Disease (VOD) remains a clinical challenge post-stem cell transplant.
  • Further research is essential to develop more effective methods for VOD prophylaxis and treatment.
  • Optimizing VOD management is crucial for improving patient outcomes in stem cell transplantation.

Related Experiment Videos