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Updated: Oct 18, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Anterior cruciate ligament injuries in the skeletally immature patient
P T Simonian1, M H Metcalf, R V Larson
1Department of Orthopedic Surgery, The University of Washington, Seattle, USA.
Abstract:
Injuries of the anterior cruciate ligament (ACL) in children are more frequent than once thought. Special factors must be taken into consideration when treating ACL injuries in the skeletally immature patient. Risks of surgery must be weighed against potential damage to the knee caused by repeated injury. The authors prefer the use of both tibial and femoral centrally placed drill holes, hamstring tendon autografts, fixation distant from the physis, and avoidance of dissection near the physis. This technique will minimize damage to the physis and should not hinder normal growth.
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