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Related Experiment Videos

Categorizing asthma severity.

G L Colice1, J V Burgt, J Song

  • 1Department of Clinical Research, 3M Pharmaceuticals, St. Paul, Minnesota 55144-1000, USA.

American Journal of Respiratory and Critical Care Medicine
|December 10, 1999
PubMed
Summary
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Nocturnal asthma symptoms significantly influenced severity categorization, potentially skewing treatment recommendations. A validated method is crucial for effective stepped care asthma pharmacotherapy.

Area of Science:

  • Pulmonology
  • Clinical Pharmacology
  • Respiratory Medicine

Background:

  • The National Asthma Education and Prevention Program (NAEPP) Expert Panel II recommends stepped care pharmacotherapy for asthma.
  • Asthma severity is objectively assessed using daytime symptoms, nocturnal symptoms, and lung function.
  • Overall asthma severity is determined by the worst grade among individual variables.

Purpose of the Study:

  • To evaluate the impact of individual asthma severity variables on overall categorization.
  • To assess the correlation between different asthma severity assessment variables.
  • To determine if a single variable predominantly influences asthma severity classification.

Main Methods:

  • Analysis of pretreatment data from five clinical trials involving 744 inhaled steroid nonusers and 685 inhaled steroid users.

Related Experiment Videos

  • Categorization of asthma severity based on daytime symptoms, nocturnal symptoms, wheeze, beta-agonist use, and FEV(1).
  • Comparison of severity grading between different variables and patient populations (US vs. European).

    • Main Results:

    • Nocturnal symptoms classified the majority of nonusers as severe, persistent.
    • Wheeze classified a significant portion of nonusers as mild, intermittent or mild, persistent.
    • Using the worst grade from four symptoms resulted in most patients categorized as severe, persistent; beta-agonist use and FEV(1) classified most as moderate, persistent.
    • Poor correlation was observed between variables in severity categorization.
    • Severity grading was similar for European and U.S. patients.

    Conclusions:

    • Nocturnal asthma symptoms significantly influenced overall asthma severity categorization in this dataset.
    • The current method, relying on the worst grade of individual variables, may lead to varied categorization patterns.
    • Development of a validated asthma severity categorization method is essential for effective stepped care pharmacotherapy.