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[Universal influenza vaccine still far in the future]
G F Rimmelzwaan1, A D Osterhaus
1Nationaal Influenza Centrum van de Wereldgezondheidsorganisatie, Erasmus Universiteit, afd. Virologie, Rotterdam.
Nederlands Tijdschrift Voor Geneeskunde
|December 10, 1999
Abstract:
Recent publications suggest that a universal vaccine against human influenza might be feasible. The vaccine would be based on the M2 protein of influenza A viruses. As yet application of such a universal vaccine seems to be far away, however, since so far only pre-clinical data in a mouse model have been generated. Furthermore, the M2 protein is only present in influenza A viruses and is known to be a minor viral antigen. In addition it may become more variable when it is exposed to immunity in the vaccinated population.