Methotrexate and emerging therapies

Area of Science:

• Rheumatology
• Pharmacology
• Clinical Medicine

Background:

• Methotrexate (MTX) is the most frequently published drug regarding its clinical efficacy and toxicity in rheumatic diseases.
• Extensive evidence supports evidence-based medicine for guiding MTX use in clinical practice.

Purpose of the Study:

• To highlight the established role of methotrexate in rheumatic diseases.
• To discuss the trend of combining MTX with novel therapies for improved outcomes.

Main Methods:

• Literature review of publications on methotrexate in rheumatic diseases.
• Analysis of current trends in combination therapy.

Main Results:

• Methotrexate has a vast body of literature detailing its efficacy and toxicity.
• Combination therapies involving MTX are increasingly used to achieve greater therapeutic responses.

Conclusions:

• Clinicians can confidently use methotrexate based on extensive evidence.
• The combination of methotrexate with novel agents is a growing trend in managing rheumatic diseases.