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Methotrexate and leflunomide combination therapy for patients with active rheumatoid arthritis
P J Mroczkowski1, M E Weinblatt, J M Kremer
1Division of Rheumatology, Albany Medical College, New York 12208-3479, USA.
Clinical and Experimental Rheumatology
|December 10, 1999
Abstract:
An open-label, one-year study was conducted to evaluate the safety and clinical response to leflunomide and methotrexate combination therapy for rheumatoid arthritis. Study results revealed tolerable safety, no significant pharmacokinetic interactions between methotrexate and leflunomide, and suggested improved clinical response with combination therapy.