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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Published on: February 14, 2017

[Progress in research of the blood coagulation system]

H Urano1, Y Karasaki, A Shirahata

  • 1Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Journal of UOEH
|December 10, 1999
PubMed

Blood coagulation is an amplification system consisting of reactions between enzymes and zymogens. It has been illustrated as a cascade model. However, the exact mechanism by which haemostasis is achieved under physiological conditions remains to be clarified. The solving of structure-function relation of each coagulation factor, analysis of the enzymological characteristics of each reaction, analysis of the regulation mechanism of the reactions and identification of novel factors involved in coagulation reactions contribute to the understanding of this complex system. Based on these findings, some new conceptions of blood coagulation are proposed. In the model introduced in this review, the extrinsic pathway and the intrinsic pathway of the 'classical' cascade model of the blood coagulation system could not be separated, and the suppression of fibrinolysis by TAFI (thrombin activatable fibrinolysis inhibitor) during coagulation reactions is thought to be a critical process for effective haemostasis.

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