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Gastrointestinal pharmacology.

D E Freeman1

  • 1College of Veterinary Medicine, University of Illinois at Urbana-Champaign, USA. dfreeman@cvm.uiuc.edu

The Veterinary Clinics of North America. Equine Practice
|December 10, 1999
PubMed
Summary

Pharmacologic management of equine gastrointestinal diseases, including ulcers and colic, requires careful drug selection. Awareness of potential harms from nonsteroidal anti-inflammatory drugs and antibiotics is crucial for safe and effective treatment.

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Area of Science:

  • Equine internal medicine
  • Veterinary pharmacology
  • Gastroenterology

Background:

  • Pharmacologic interventions are essential for managing various equine gastrointestinal diseases.
  • Common conditions include gastric ulcers, colic, diarrhea, reperfusion injury, postoperative ileus, and adhesions.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics are frequently used but carry significant risks.

Purpose of the Study:

  • To review the pharmacologic management of equine gastrointestinal diseases.
  • To highlight the benefits and risks associated with commonly used medications.
  • To emphasize cautious and evidence-based drug selection.

Main Methods:

  • Literature review of pharmacologic treatments for equine gastrointestinal disorders.
  • Analysis of the physiological effects of NSAIDs on the equine intestine.
  • Discussion of the controversial role and risks of antibiotics in equine gastrointestinal disease.

Main Results:

  • Specific drugs like omeprazole, laxatives, analgesics, antibiotics, and prokinetic drugs are indicated for various conditions.
  • NSAIDs, while valuable analgesics, can negatively impact intestinal physiology.
  • Antibiotics can induce severe diarrhea, necessitating judicious use.

Conclusions:

  • Effective pharmacologic management of equine GI diseases requires a balanced approach, weighing benefits against risks.
  • Careful consideration of NSAID and antibiotic use is paramount to avoid adverse effects.
  • Veterinarians must exercise caution and employ defensible strategies when prescribing these medications.

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