Related Experiment Video
Updated: Jul 31, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Pathogenesis of amyotrophic lateral sclerosis: a critical review
1Department of Neurology, University of Utah, Salt Lake City 84132, USA. mbromberg@msscc.med.utah.edu
Abstract:
Amyotrophic lateral sclerosis is a neurodegenerative disease with unknown pathogenesis. It is a relatively common disorder of adults (2-4 per 100,000 incidence) and leads to death from respiratory failure. There is no cure at this time, and available treatment and management can at best extend survival to a modest degree. Increasing our understanding of the pathogenesis of this disease is essential to the development of more effective treatments. The level of research interest is very high, and yearly reviews of the literature are helpful in assessing progress.
Related Concept Videos
Cross-bridge Cycle
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Parkinson's Disease: Overview
Alzheimer Disease ll: Pathophysiology
Parkinson Disease ll: Pathophysiology
Myasthenia Gravis ll: Pathophysiology

