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Related Experiment Videos

Properdin: initiation of alternative complement pathway.

D T Fearon, K F Austen

    Proceedings of the National Academy of Sciences of the United States of America
    |August 1, 1975
    PubMed
    Summary
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    The complement system

    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • The classical complement pathway initiates cell lysis via C3 and C5 cleavage.
    • An alternative pathway involves properdin (P) and factor D (D) for complement activation.

    Purpose of the Study:

    • To investigate the mechanisms of complement C3 cleavage and C3 convertase formation.
    • To elucidate the roles of properdin (P) and factor D (D) in alternative pathway activation.

    Main Methods:

    • Studied the interaction of complement components C3, factor B (B), factor D (D), and properdin (P).
    • Assessed C3 inactivation and convertase formation under various conditions.

    Main Results:

    • Initial C3 cleavage occurs with C3 and B in the presence of D or P alone or together.

    Related Experiment Videos

  • Properdin (P) stabilizes the C3 convertase (C3B), preventing decay.
  • A novel C3 convertase, (P)C3B, forms with P and B without D, dependent on P and B concentrations.

    • Conclusions:

    • Factor D (D) is crucial for uncovering the active site of factor B (B) in C3 convertase formation.
    • Properdin (P) plays a dual role: stabilizing C3 convertase and facilitating C3 cleavage independently of factor D (D).
    • These findings clarify the intricate regulation of complement activation pathways.