Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Varicocele-associated decrease in antioxidant defenses.

E R Barbieri1, M E Hidalgo, A Venegas

  • 1Faculty of Science, University of Valparaíso, Chile.

Journal of Andrology
|December 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of sex in daily levels of high-risk alcohol and cannabis co-use.

Drug and alcohol dependence reports·2023
Same author

Effect of ageing on the availability of heavy metals in soils amended with compost and biochar: evaluation of changes in soil and amendment properties.

Environmental science and pollution research international·2016
Same author

Thiol-induced hemoglobin oxidation.

Redox report : communications in free radical research·2016
Same author

Response of unilamellar DPPC and DPPC:SM vesicles to hypo and hyper osmotic shocks: A comparison.

Chemistry and physics of lipids·2015
Same author

Inactivation of the pore-forming toxin Sticholysin I by peroxynitrite: protection by cys groups incorporated in the toxin.

The protein journal·2014
Same author

Viability of organic wastes and biochars as amendments for the remediation of heavy metal-contaminated soils.

Chemosphere·2014
Same journal

Special Section: Commemorating the Journal of Andrology's Distinguished History.

Journal of andrology·2012
Same journal

Parting messages from current and former editors of the Journal of Andrology.

Journal of andrology·2012
Same journal

Evolution of the Journal of Andrology and a bright future for Andrology.

Journal of andrology·2012
Same journal

Management of erectile dysfunction: great progress, greater promise.

Journal of andrology·2012
Same journal

Aging and declining testosterone: past, present, and hopes for the future.

Journal of andrology·2012
Same journal

The genetics of male fertility--from basic science to clinical evaluation.

Journal of andrology·2012
See all related articles

Varicocele patients exhibit reduced antioxidant defenses in both seminal and blood plasma, indicating systemic oxidative stress. This oxidative stress is linked to varicocele and may impact sperm health.

Area of Science:

  • Reproductive Medicine
  • Oxidative Stress Research
  • Urology

Background:

  • Varicocele, a common cause of male infertility, is increasingly linked to oxidative stress.
  • Oxidative stress can impair sperm function and reduce fertility outcomes.

Purpose of the Study:

  • To investigate antioxidant defenses in varicocele patients at both local (seminal plasma) and systemic (blood plasma) levels.
  • To determine if varicocele-associated oxidative stress affects antioxidant potential in bodily fluids.

Main Methods:

  • Measurement of total reactive antioxidant potential (TRAP) in seminal and blood plasma.
  • Comparison of TRAP levels between varicocele patients and control groups.
  • Assessment of urinary spontaneous chemiluminescence as an indicator of oxidative stress.

Related Experiment Videos

Main Results:

  • Antioxidant defenses, measured by TRAP, were significantly decreased in both seminal plasma (patients: 386+/-186 vs. controls: 676+/-128) and blood plasma (patients: 268+/-110 vs. controls: 519+/-63) of varicocele patients.
  • Reduced antioxidant potential was observed even in patients with normal spermiograms, suggesting systemic effects.
  • Increased urinary spontaneous chemiluminescence in patients further supported the presence of elevated oxidative stress.

Conclusions:

  • Varicocele is associated with a significant reduction in antioxidant defenses at both local and systemic levels.
  • Oxidative stress is a key factor in varicocele pathophysiology, impacting overall health and potentially fertility.
  • These findings highlight the need for therapeutic strategies targeting oxidative stress in varicocele management.