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[Metaplastic meningioma with cartilaginous differentiation]
C Becker1, K Kuchelmeister, H P Richter
1Institut für Neuropathologie, Justus-Liebig-Universität Giessen.
Der Pathologe
|December 11, 1999
Summary
This case study describes a rare metaplastic meningioma with extensive cartilaginous differentiation. Identifying typical meningioma areas is crucial for diagnosing this uncommon variant.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Meningiomas are tumors arising from the meninges.
- Metaplastic meningiomas exhibit differentiation into non-meningothelial mesenchymal elements.
- Cartilaginous metaplasia is an uncommon feature within meningiomas.
Observation:
- A rare meningioma with significant cartilaginous areas was identified.
- The tumor originated near the right sphenoid wing in a 74-year-old female patient.
- Histological examination revealed typical meningothelial areas interspersed with cartilaginous islands and chondroid regions, indicating intermediate differentiation.
Findings:
- Lower MIB1-labelling indices were observed in cartilaginous areas compared to typical meningioma regions.
- Focal increased proliferative activity was noted in the meningothelial portions.
- The World Health Organization (WHO) classification recognizes these as metaplastic meningiomas, highlighting mesenchymal differentiation potential.
Implications:
- This case underscores the diverse metaplastic potential of meningioma cells.
- Extensive cartilaginous metaplasia, while rare, is a recognized variant.
- Accurate diagnosis hinges on identifying both the metaplastic and typical meningioma components.