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MIPS: a database for genomes and protein sequences.

H W Mewes1, D Frishman, C Gruber

  • 1GSF-Forschungszentrum für Umwelt und Gesundheit, Munich Information Center for Protein Sequences, am Max-Planck-Institut für Biochemie, Am Klopferspitz 18, D-82152 Martinsried, Germany. mewes@mips.embuct.org

Nucleic Acids Research
|December 11, 1999
PubMed
Summary
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The Munich Information Center for Protein Sequences (MIPS-GSF) develops and maintains high-quality curated genome databases. These bioinformatics resources support sequencing and functional analysis projects, offering access to diverse genomic data.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The Munich Information Center for Protein Sequences (MIPS-GSF) has a history of developing curated genome databases.
  • There is an increasing need to systematically cover and manage complete genome sequences.

Purpose of the Study:

  • To report on the development and maintenance of high-quality, curated genome databases.
  • To showcase bioinformatics efforts supporting national and European sequencing and functional analysis projects.
  • To describe several growing genome-oriented databases.

Main Methods:

  • Database development and curation.
  • Bioinformatic analysis of genomic and protein sequence data.
  • Integration of functional analysis data.

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Main Results:

  • MIPS-GSF has intensified efforts to systematically cover complete genome sequences.
  • Several growing databases are described, including MATDB (Arabidopsis thaliana), MNCDB (Neurospora crassa), MYGD (yeast), HIB (human EST-clusters), and DHGP (German Human Genome Project) cDNA sequences.
  • Databases for complete genomes (PEDANT), protein classification (ProtFam), and protein sequence data (PIR-International) are also available.

Conclusions:

  • MIPS-GSF provides essential bioinformatics resources for genomic research.
  • These databases facilitate access to comprehensive and up-to-date genomic and protein sequence information.
  • The MIPS WWW server offers access to these valuable research tools.