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The protein information resource (PIR).

W C Barker1, J S Garavelli, H Huang

  • 1Protein Information Resource, National Biomedical Research Foundation, 3900 Reservoir Road, NW, Washington, DC 20007, USA. pirmail@nbrf.georgetown.edu

Nucleic Acids Research
|December 11, 1999
PubMed
Summary
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The Protein Information Resource (PIR) offers a comprehensive protein sequence database with enhanced web search tools. These tools aid in protein analysis and functional identification through advanced searching capabilities.

Area of Science:

  • Bioinformatics
  • Proteomics
  • Computational Biology

Background:

  • The Protein Information Resource (PIR) is a key provider of public protein sequence data.
  • Existing search functionalities required enhancement for more sophisticated protein analysis.

Purpose of the Study:

  • To introduce expanded web-based search capabilities for the PIR-International Protein Sequence Database.
  • To facilitate protein analysis and functional identification through improved data retrieval.

Main Methods:

  • Development of new web-based search engines integrating sequence similarity and annotation data.
  • Implementation of advanced search options including annotation-sorted, domain, and combined global/domain searches.
  • Provision of interactive text search functionalities.

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Main Results:

  • The expanded PIR WWW site now offers enhanced sequence similarity and text searching.
  • New search engines enable combined analysis of sequence similarity and database annotations.
  • Advanced search capabilities improve the efficiency of protein identification and analysis.

Conclusions:

  • The enhanced PIR WWW site and search tools significantly improve access to and analysis of protein sequence data.
  • These advancements support researchers in protein functional identification and bioinformatics studies.
  • The PIR-International Protein Sequence Database remains a vital resource for the scientific community.